The Department of Chemistry, Mehsana Urban Institute of Sciences, Ganpat University organized a “International Webinar on Artificial intelligence driven Bioinformatics: Precision medicine, Clinical diagnosis and prognosis” on 18th Jan 2021. Conveners of this event are Dr. Amit Parikh (Principal), and Dr. Keyur D. Bhatt (Head, Chemistry) welcome the expert. The program of action includes one hour expert’s talk by Dr. Srinivas Kolluru, Department of Medicinal Chemistry, University of Kansas, Lawrence, KS-USA. The talk focused on Catalytic Functionalization of
Benzofurans and Total Synthesis of Anticancer Natural products - Propolisbenzofuran B & (-)- Pavidolide B. Benzofuran constitutes the structure core of several biological active natural products and pharmaceutical drugs such as Amiodarone, Benzbromarone, Dronedarone, and Budiodarone. These drugs have severe side effects and especially Benzbromarone was withdrawn from the market following its adverse side effects. Dr. Naresh Bhuma, Erik Chorell group, Umeå University, Umeå, Sweden. . The talk focused on Design and Synthesis of Small Molecules for Stabilization of G-Quadruplex DNA Structures. Guanine rich DNA sequences have the propensity to adopt four strand tetrahelical G-quadruplex (G4) structures in presence of monovalent cations like Na+, K+. G4 DNA structures are linked to fundamental biological processes and diseases. Computational studies have suggested ~376000 putative G4 forming sequences existing in the human genome.